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Name
fMRIstat
Byline
Montreal Neurological Institute
Description
FMRIstat implements a method for the statistical analysis for fMRI data that seeks a compromise between efficiency, generality, validity, simplicity and execution speed. The main differences between this analysis and previous ones are: a simple bias reduction and regularization for voxel-wise autoregressive model parameters; the combination of effects and their estimated standard deviations across different scans/sessions/subjects via a hierarchical random effects analysis using the EM algorithm; overcoming the problem of a small number of scans/session/subjects using a regularized variance ratio to increase the degrees of freedom.

FMRIstat also implements a fast, efficient, general, simple, valid and robust method of estimating and making inference about the delay of the fMRI response modeled as a temporal shift of the hemodynamic response function (HRF). We estimate the shift unbiasedly using two optimally chosen basis functions for a spectrum of time shifted HRFs. This is done at every voxel, to create an image of estimated delays and their standard deviations. This can be used to compare delays for the same stimulus at different voxels, or for different stimuli at the same voxel.
NIfTI-1 support
Yes
Creator
Keith Worsley
Contact
keith.worsley@mcgill.ca
WWW
www.math.mcgill.ca/keith/fmristat
Availability
free
How to get
Go to www.math.mcgill.ca/keith/fmristat
Current version
Jan 2006
Current version release date
Jan 2006
Open source
Yes
License
none
Available free of charge
Yes
Requirements
Matlab
Technical publications
Worsley, K.J., Liao, C., Aston, J., Petre, V., Duncan, G.H., Morales, F., Evans, A.C. (2002). A general statistical analysis for fMRI data. NeuroImage, 15:1-15.

Liao, C., Worsley, K.J., Poline, J-B., Aston, J.A.D., Duncan, G.H., Evans, A.C. (2002). Estimating the delay of the fMRI response. NeuroImage, 16:593-606.

Worsley, K.J. & Taylor, J.E. (2005). Detecting fMRI activation allowing for unknown latency of the hemodynamic response. Neuroimage, in press.

Worsley, K.J. (2005). Spatial smoothing of autocorrelations to control the degrees of freedom in fMRI analysis. NeuroImage, 26:635-641.

Worsley, K.J. (2005). An improved theoretical P-value for SPMs based on discrete local maxima. NeuroImage, in press.
Applications publications
Worsley, K.J., Liao, C., Aston, J., Petre, V., Duncan, G.H., Morales, F., Evans, A.C. (2002). A general statistical analysis for fMRI data. NeuroImage, 15:1-15.

Liao, C., Worsley, K.J., Poline, J-B., Aston, J.A.D., Duncan, G.H., Evans, A.C. (2002). Estimating the delay of the fMRI response. NeuroImage, 16:593-606.

Worsley, K.J. & Taylor, J.E. (2005). Detecting fMRI activation allowing for unknown latency of the hemodynamic response. Neuroimage, in press.

Worsley, K.J. (2005). Spatial smoothing of autocorrelations to control the degrees of freedom in fMRI analysis. NeuroImage, 26:635-641.

Worsley, K.J. (2005). An improved theoretical P-value for SPMs based on discrete local maxima. NeuroImage, in press.
Other information
Keywords
functional, statistical
Platforms
MATLAB
IATR listing last updated
22 Dec 2005