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Name
TOPPCAT
Byline
Duke University Medical Center
Description
TOPPCAT stands for T-One weighted Perfusion imaging Parameter CAlculation Toolkit. TOPPCAT creates quantitative maps of Ktrans (volume transfer constant between blood plasma and the extravascular extracellular space) and fPV (fractional plasma volume) from dynamic T1-weighted perfusion images. At the current time, analysis using the method of Patlak plots (most appropriate for first pass dynamic contrast-enhanced MR imaging) is supported. As a preliminary step for the parameter calculation, TOPPCAT also creates maps of T1 and S0 (equilibrium magnetization) from multi-flip angle T1-weighted SPGR (or FLASH) sequences.
NIfTI-1 support
Creator
Daniel Barboriak, MD, Anthony Padua, James MacFall, PhD
Contact
Anthony Padua - padua001@mc.duke.edu
WWW
http://dblab.duhs.duke.edu
Availability
How to get
Available after registering and request at website -- http://dblab.duhs.duke.edu
Current version
1.4
Current version release date
1/9/05
Open source
No
License
Available w/o fee & w/o signed licensing agreement
Available free of charge
Yes
Requirements
TOPPCAT runs as plugins to ImageJ. ImageJ (rsb.info.nih.gov/ij/) must be installed before the TOPPCAT plugins.
Technical publications
Daniel P. Barboriak, James R. MacFall, Anthony O. Padua, Gerald E. York, Benjamin L. Viglianti, and Mark W. Dewhirst. Standardized software for calculation of Ktrans and vp from dynamic T1-weighted MR images. Presented at the International Society for Magnetic Resonance in Medicine Workshop on MR in Drug Development: From Discovery to Clinical Therapeutic Trials, McLean VA, April 2004
Applications publications
none
Other information
TOPPCAT user's guide available at website.
Keywords
ImageJ, Java, Ktrans, MR imaging, perfusion
Platforms
Linux, MacOS, UNIX, Windows
IATR listing last updated
08 Sep 2005