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AFNI is a set of C programs for processing, analyzing, and displaying functional MRI (FMRI) data. It is freely distributed (in source code format, and some precompiled binaries) for research purposes.

Since AFNI is free, all users are "beta testers for life". The code is updated frequently in response to bug reports and feature creep. There is no support guarantee, but in practice you can usually get a quick response by posting problems/questions on the AFNI Message Board.
NIfTI-1 support
Version AFNI_2005_09_06_0927 (current release) : supports reading and writing of NIfTI-1.1 images -- see for more details.
Robert W Cox, PhD
now and forever, one and inseparable
How to get
See Website.
Current version
(automatically updated nightly)
Current version release date
December 21, 2011
(automatically updated nightly)
Open source
Available free of charge
  • AFNI runs under Unix/Linux and Mac OS X (to a limited extent on Windows via Cygwin).
  • It is probably best to recompile the source code yourself, which requires an ANSI C compiler and X11/Motif libraries. However, binaries are available for some configurations (Linux, Solaris, Mac OS X, Irix).
  • Some operations are quite memory intensive (e.g., volume registration). We recommend at least 2 GB of RAM. And, of course, all the disk space in the world.
Technical publications

1. RW Cox. AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers and Biomedical Research, 29:162-173, 1996.

2. RW Cox and JS Hyde. Software tools for analysis and visualization of FMRI Data. NMR in Biomedicine, 10:171-178, 1997.

3. RW Cox and A Jesmanowicz. Real-time 3D image registration for functional MRI. Magnetic Resonance in Medicine, 42: 1014-1018, 1999.
Applications publications

First 3 of more than 200 listed at

1. Binder JR, Frost JA, Hammeke TA, et al. Human brain language areas identified by functional magnetic resonance imaging. J NEUROSCI 17: (1) 353-362 JAN 1 1997

2. Braver TS, Cohen JD, Nystrom LE, et al. A parametric study of prefrontal cortex involvement in human working memory NEUROIMAGE 5: (1) 49-62 JAN 1997

3. Cohen JD, Perlstein WM, Braver TS, et al. Temporal dynamics of brain activation during a working memory task. NATURE 386: (6625) 604-608 APR 10 1997
Other information
  • AFNI incorporates much of the Talairach Daemon database from RIC/UTHSCSA (Fox and Lancaster).
functional, NIfTI-1 support, registration, statistical, surface analysis, visualization, volume
IRIX, Linux, MacOS, SunOS, UNIX
IATR listing last updated
21 Sep 2005