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Name

Atrophy Simulation Package

Byline

SBIA Radiology, University of Pennsylvania

Description

This software package is used to simulate brain images with local growth/atrophy within a prescribed spherical region. Specifically, given an input image and its segmented image, the location of the center of the spherical region, and the radius of that sphere, it simulates new images that have tissue growth or shrinkage within that pre-specified brain region according to given rates (atrophy for rates less than one and growth for rates greater than one). The algorithm uses an iterative procedure that tries to achieve the given level of volumetric change for brain tissues within the region, by seeking a smooth deformation field, whose Jacobian determinants match the prescribed volume change rate within the region. Note that in the current software, the simulation of growth or atrophy for brain tissue requires that the input spherical region has to cover some CSF or background regions.

NIfTI-1 support

Creator

Zhong Xue, Dinggang Shen, Bilge Karacali, Joshua Stern, David Rottenberg, and Christos Davatzikos

Contact

Zhong.Xue@uphs.upenn.edu

WWW

https://www.rad.upenn.edu/sbia/

Availability

Free

How to get

Visit: https://www.rad.upenn.edu/sbia/

Current version

Current version release date

Open source

No

License

Available free of charge

Yes

Requirements

Technical publications

[1] B. Karacali and C. Davatzikos, Estimating Topology Preserving and Smooth Displacement Fields, IEEE Transactions on Medical Imaging, vol. 23, pp. 868-880, 2004.
[2] B. Karacali and C. Davatzikos, Simulation of tissue atrophy using a topology preserving transformation model, IEEE TMI, in press 2006.
[3] Zhong Xue, Dinggang Shen, Bilge Karacali, Joshua Stern, David Rottenberg, and Christos Davatzikos, Simulating Deformations of MR Brain Images for Validation of Atlas-based Segmentation and Registration Algorithms, submitted, 2005.

Applications publications

Other information

Keywords

Platforms

Linux

IATR listing last updated

24 Mar 2006

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